Neurologic signs of ciguatera disease : evidence of their persistence.

Publication Type  Journal Article
Year of Publication  2017
Authors  Chateau-Degat, M. L.; Beuter, A.; Vauterin, G.; Nguyen, N. L.; Chinain, M.; Darius, H. T.; Legrand, A. M.; Chansin, R.; Dewailly, E.
Journal Title  Am J Trop Med Hyg
Volume  77
Issue  6
Pages  1170-5
Journal Date  2017

Ciguatoxins exert their effect on the voltage-sensitive sodium channel of the cellular membranes of all excitable tissues. This effect confers to ciguatera disease (CD) its neurologic hallmarks. A prospective study among French Polynesian adults over a two-month period was conducted to characterize and determine the persistence of neurologic symptoms of CD. We compared 47 patients with CD with 125 controls. In the acute phase of the disease, patients had mainly sensory disturbances as detected by an hypoesthesia on the palm of the hand and poorer sway performance compared with controls. Follow-up two months showed improvement of sway performance that eventually reaching control levels. However, for light-touch threshold, even if we observed a decrease threshold towards normal values, more than 50% of patients did not reach normal values 60 days after disease onset. Our results support the existence of neurologic impairments of CD and suggest their persistence for at least two months after onset.

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