0 Levee, G. Schurr, E. Pandey, J. P. 1997 Exp Clin Immunogenet 14 2 160-165 1997 In order to determine the genetic components of susceptibility to leprosy in 6 multiplex French Polynesian families, linkage analysis was carried out between a putative disease gene and 6 polymorphic loci : G1M, G2M, KM, IL-1 beta, TNF-alpha (1,2) and TNF-alpha (A,G) using the lod score method. The three modes of inheritance, assuming a full penetrance value or reduced penetrance values (80 and 40%) for the susceptible allele, as well as with affected ones only, were tested. The results of this study provide no evidence for linkage between leprosy and the markers tested.